Drew Barrymore and Toni Collette are Best Friends in the 'Miss You Already' Trailer

While Catherine Hardwicke's Miss You Already deals with cancer, chemotherapy, pregnancy problems, and other issues usually reserved for more serious dramas, the tone of this trailer is decidedly upbeat. It's a difficult balance between sadness and joy she seems to be walking, but stars Drew Barrymore and Toni Collette seem to be up for the challenge of depicting two life-long friends coping with those difficult issues. Here's the official synopsis:

MISS YOU ALREADY is an honest and powerful story following two best friends, Milly (Toni Collette) and Jess (Drew Barrymore), as they navigate life’s highs and lows. Inseparable since they were young girls, they can’t remember a time they didn’t share everything –secrets, clothes, even boyfriends -- but nothing prepares them for the day Milly is hit with life-altering news. A story for every modern woman, MISS YOU ALREADY celebrates the bond of true friendship that ultimately can never be broken, even in life’s toughest moments.

Also starring Dominic Cooper, Jacqueline Bisset, Tyson Ritter, and Paddy Considine, Miss You Already debuts at TIFF later this month and hits theaters on November 6th.