Robert De Niro and Edgar Ramirez step into the ring for 'Hands of Stone'

After the success of The Fighter back in 2010, boxing movies were suddenly back in vogue. A sequel to the David O. Russell drama was bandied about, and still may happen, along with Southpaw which at the time would have starred Eminem. One of the most promising of all was Hands of Stone, a biopic on Hall of Fame boxing champ Roberto Duran. At the time, Gael Garcia Bernal was set to play Duran, with Al Pacino as his longtime trainer Ray Arcel, but those plans have now changed in a major way.

Robert De Niro and Edgar Ramirez will headline the film, which follows Duran's career during one of boxing's golden eras. Fighting the likes of Hector Camacho, Thomas "Hitman" Hearns, and Marvin Hagler, Duran won 103 of his 119 bouts, earning the nickname "Hands of Stone" by knocking out 70 opponents. The story will mostly center on his matches against Sugar Ray Leonard, including the famous incident in which Duran quit and exited the ring during the final round , crying "No Mas" after taking a particularly bad beating.

Jonathan Jakubowicz is in line to direct and produce Hands of Stone, which may or may not still have Usher getting into fighting shape to play Leonard. De Niro starred in one of the most iconic boxing films ever in Raging Bull, and will be taking on the sweet science again opposite Sylvester Stallone in Grudge Match.  After making his breakout in Domino, Ramirez has come into his own and is now on the verge of becoming one of today's top leading men. He had a small but pivotal role in Kathryn Bigelow's Zero Dark Thirty, and is set to play Venezualan leader Simon Bolivar in Libertador. [Deadline]